Job Title: Scientist I/II
Line Manager: Head of Early Validation
Team: Cell & Tissue Biology
Location: Taipei City, Taiwan
Contract: Permanent
Summary
We are looking for a talented and highly motivated scientist to join the Ochre Bio Team in TPE on an exciting journey to support the development of advanced RNA medicines for one of the most pressing healthcare challenges of our time.
Ochre’s Taipei site is a highly unique precision-slice liver culture lab that deep phenotypes human liver biopsies from diseased donor patients and study their responses to advanced RNA therapies. Deep phenotyping of liver tissue slices includes: tissue imaging, functional assays, bulk/single-cell sequencing, to model disease and therapeutic dynamics over extended culture time. The team also uses functional genomics, perturbation assays and large scale primary human cell culture/co-culture models to increase scale and throughput of generate discovery datasets and drug candidate screening.
This role will be responsible for generating experimental data from Taipei lab, to support cell and tissue assays for early validation of Ochre’s drug discovery candidates. We are looking for well-rounded scientists who can keep to deadlines in a fast-paced environment and be part of a collaborative team. You will be expected to work alongside senior scientists to rapidly optimise challenging assays, imaging, and omic outputs. Experimental experience in liver and metabolic disorders, 2D/3D precision cut tissue and cell cultures, high-content imaging, single cell/spatial transcriptomics, CRISPR-Cas9, RNAi screens and excellent proficiency in molecular biology and biochemistry will be highly advantageous. We welcome fresh Ph.Ds and Post Docs who would like to make the switch to industrial research environment. You will report to the Head of Early Validation (site head), working closely with the rest of cell and tissue team to generate robust data,
This role will be based at National Biotechnology Research Park at Nangang, Taipei.
Key Responsibility
● Drive innovation by developing and executing state of the art primary cell and tissue culture and phenotyping assays
● Lead the design and execution of experimental plans, actively participating in the cell and tissue culture workflows
● Analyse, review and interpret results
● Actively collaborate and communicate with other members of Ochre Bio across all three sites (US, UK & Taiwan)
● Record experiments according to maintain full traceability of all reagents and samples
● Support junior associate scientists in the lab
● Proactively contribute to the smooth running of the laboratory, including managing external suppliers and collaborators.
● Compile data decks on experiments, present data and conclusions to wider teams
Qualification and Experience
Required
● PhD degree in a biological science or MSc with equivalent industry experience
● Track record of scientific contributions including peer-reviewed first-author publications, patent applications, and/or presentations at major conferences
Skill and Competence
Required
● Strong expertise with lab-based assays such as qPCR, western blots, immunofluorescence, cell-based assays and flow cytometry
● Experience with cellular models using sterile techniques
● Comfortable with omic’s such as proteomics, metabolomics and transcriptomics
● Highly organised and methodical approach to work and record keeping
● Self-motivated, technically competent and capable of working independently within the laboratory
● Ability to adapt to changing demands whilst working within a team to tight deadlines
● Proactiveness in identifying and addressing issues
● High-level of attention to detail
● Excellent interpersonal skills
● Embracing change - this is a fast-growing company and change is inevitable!
Desirable
Ability to analyse and present data using R is highly desirable, and will be required on the job.
待遇面議
