Job Title: Senior/Principal Scientist
Line Manager: Head of Early Validation
Team: Cell & Tissue Biology
Location: Taipei City, Taiwan
Contract: Permanent
Summary
We are looking for a talented and highly motivated senior/principal scientist to join the Ochre Bio Team in TPE on an exciting journey to support the development of advanced RNA medicines for one of the most pressing healthcare challenges of our time.
Ochre’s Taipei site is a highly unique precision-slice liver culture lab that deep phenotypes human liver biopsies from diseased donor patients and studies their responses to advanced RNA therapies. Deep phenotyping of liver tissue slices includes: tissue imaging, functional assays, bulk/single-cell sequencing, to model disease and therapeutic dynamics over extended culture time. The team also uses functional genomics, perturbation assays and large scale primary human cell culture/co-culture models to increase scale and throughput of generating discovery datasets and drug candidate screening.
This role will be responsible for driving innovation using the ex-vivo human precision slice culture and human primary cell culture to better study liver fibrosis and regeneration and for early validation of Ochre’s drug discovery candidates. We are looking for well-rounded scientists who can keep to deadlines in a fast-paced environment and be part of a collaborative team. You will be expected to work alongside junior scientists to rapidly optimise culture conditions and assays to drive innovation in precision slice culture systems. Experimental experience in liver and metabolic disorders, ex vivo tissue perfusion systems, organ-on-chip, 3D organoid cultures, high-content imaging, RNAi screens will be highly advantageous. We welcome Ph.Ds and Post Docs who would like to make the switch to an industrial research environment. You will report to the Head of Early Validation (site head), working closely with the rest of cell and tissue team to generate robust data.
This role will be based at National Biotechnology Research Park at Nangang, Taipei.
Key Responsibility
● Drive innovation by developing and executing state of the art primary cell and tissue culture conditions to study liver fibrosis and regeneration
● Lead the design and execution of large scale RNAi screen in liver cells and tissue to identify new targets in liver fibrosis and regeneration
● Actively collaborate and communicate with other members of Ochre Bio across all three sites (US, UK & Taiwan) and attend meetings
● Support junior scientists in the lab
● Compile data decks on experiments, present data and conclusions to wider teams
● Participate in projects spanning all three sites (US, UK & Taiwan) and external partners
Qualification and Skills
Required
● PhD degree in a biological science or MSc with equivalent industry experience
● Track record of scientific contributions including peer-reviewed first-author publications, patent applications
● Strong command of biology, cellular models and model development
● Comfortable with large scale screens and high-throughput workflows
● Ability to adapt to changing demands whilst working within a team to tight deadlines
● Strong organisational skills, with the ability to coordinate multiple projects and prioritise tasks effectively
● Good team player
● Excellent command of English
● Embracing change - this is a fast-growing company and change is inevitable!
Desirable
● Startup biotech or industry experience
● Experience with 3D tissue and organoid culture, organ-on-chip, perfusion system, high-content imaging, large scale RNAi screens
● Ability to analyse and present data using R is highly desirable, and will be required on the job.
We'd love to hear from you:
Please apply with your CV and a cover letter clearly stating:
Your earliest start date.1-2 examples of work (or publications) you feel best highlight your scientific strengths and ability to meet demanding deadlines.
待遇面議
