「Bioinformatics Specialist」的相似工作

MAKE RESEARCH HAPPEN《陪科學家不斷前進，為科學研究提供最佳解決方案，為科學創造無限價值》 ✔生物資訊工程師工作內容 1. 協助開發與維護分析流程 2. 自動化流程與報告產出 3. 客製化案件分析 4. 內部教育訓練 ★ 其他條件 1. 熟悉 R 語言 2. 具NGS分析經驗 3. 蛋白質體學與MASS Cytometry 背景知識與實務經驗 4. 流程化工具(Snakemake)使用經驗 5. 基本Linux 操作及統計概念 6. 一年以上生物資訊實務經驗

• 利用人工智慧框架（如 TensorFlow、PyTorch）建構與訓練AI模型，解決生物資訊相關問題 • 爬取並整理公開資料庫的數據，進行資料清理與預處理，作為機器學習模型的訓練材料 • 進行次世代定序（NGS）資料分析，從大量生物資訊數據中擷取有用資訊並產出報告 • 撰寫與維護 Python 程式碼，開發數據分析工具和自動化流程，提高分析效率 其他條件： • 3年以上相關工作經驗，曾從事生物資訊分析或機器學習模型開發 • 精通 Python 程式設計，能獨立撰寫與維護程式碼；熟悉 TensorFlow、PyTorch 等深度學習框架並有實際專案經驗 • 具備次世代定序（NGS）數據分析經驗，理解基因體序列數據處理流程；熟悉資料擷取、整理與大數據分析方法

加入研究專案及指導學生Research 1. 建立模型並進行數據分析 2. 設計、實施及檢驗數據收集方法 3. 挖掘數據的潛在價值以得出相關洞見 4. 提供有效的數據解決方案 5. 編寫報告以清晰地傳達數據分析結果 熟悉生物資訊領域, 及軟體或硬體開發尤佳

【全球知名媒體《Discovery》採訪】 每個人出生時都帶有不同程度的致病基因，好萊塢女星安潔莉納裘莉透過基因檢測，進行前瞻預防性割乳手術掀起全球熱議。 大江基因透過大數據研發專利晶片基因篩檢技術解開人體秘密，更獲選Discovery頻道《台灣智慧：服務全方位》團隊專訪健樂士的健康管理模式。 大江基因透過基因檢測，評估客戶先天體質的狀況，提供精準醫療的客製化服務與專利保健保養特調，締造健康黃金盾牌。大江基因與您攜手遇見更美好的自己 ! 【職位概述】 我們正在尋找一位經驗豐富的專家，負責進行分子對接、動態模擬、電腦虛擬篩選及計算化學相關工作，以支持新型產品的開發。該職位將協助我們通過計算和模擬技術進行產品成分的研究和優化。 【工作職責】 1. Next Generation Sequencing (Illumina, ion-torrent等平台) 資料 QC 與處理。 2. 執行並協助開發次世代定序應用之生資分析服務。 3. 次世代定序流程建立與管理 (NGS pipeline)。 4. 主管交辦事宜。 【技術能力】 1. 熟練掌握分子對接(molecular docking)和動態模擬(dynamic simulation)的分析軟體（如AutoDock、GROMACS、AMBER等）的使用。 2. 了解蛋白質結構、配體化學、分子建模及其相互作用機制。 3. 進行編程（如Python、R等），編寫和優化數據處理和分析腳本。

About the Role BeOne Medicines is seeking an enthusiastic and highly motivated Senior Research Investigator / Senior Scientist with expertise in gene engineering and genome analysis to join our Cell Therapy team. The successful candidate will play a key role in developing innovative genome engineering platforms to advance next-generation cell therapies. This role is responsible for leveraging the company’s proprietary technologies to design and deliver cutting-edge engineered cell products for clinical applications. Key Responsibilities • Design, execute, and optimize gene engineering strategies (e.g., targeted knock-in/knock-out, transgene integration, advanced editing technologies) in mammalian cells to meet project goals. • Independently derive, screen, and characterize engineered clones with strong hands-on execution, integrating molecular biology and genome analysis, while supporting routine lab maintenance to ensure efficient workflows. • Support NGS-based analyses (Illumina etc.) to evaluate desired modifications and genome stability. • Collaborate with bioinformatics, discovery, and development teams to deliver high-quality engineered cell therapy products. • Present scientific data and engage colleagues in technical discussions at internal project meetings. • Maintain a strong laboratory presence and contribute to an innovative, collaborative team environment. Qualifications Required: • PhD in Molecular Biology, Gene/Genome Engineering, Immunology, bioinformatics or related biological sciences with ≥3 years of relevant experience. (academic experience post-graduate also considered) • MS in Molecular Biology, Gene/Genome Engineering, Immunology, bioinformatics or related biological sciences with ≥5 years of relevant experience. • Proven hands-on experience with gene engineering technologies (e.g., CRISPR, viral vector, TALEN, mRNA delivery platforms) in mammalian cells (e.g., knock-in/out, transgene insertion, targeted modifications). • Strong molecular biology skills (e.g., cloning, PCR/qPCR/dPCR, Sanger sequencing, NGS analysis). • Knowledge or experience in developing and characterizing engineered cells. • Demonstrated ability to work in a dynamic, fast-paced environment with strong teamwork and problem-solving skills. • Excellent organizational and communication skills; proven ability to manage multiple projects under tight timelines. Preferred: • Experience with engineered cell therapy or gene therapy development (iPSC, MSC, T cells, NK, stem cell). • Familiarity with bioinformatics, pathway analysis, or NGS data interpretation. • Experience with advanced molecular biology techniques and flow cytometry. • Knowledge of genome analysis approaches for engineered cell therapy products.

1. 基因檢測產品開發。 2. 期刊文獻收集閱讀。 3. 分析次世代定序實驗數據。 4. 執行次世代定序實驗與導入新興技術與應用。 5. 主管交辦事項。 【加分(薪)項目】 1. 具認證實驗室工作經驗，如 CAP、TAF/ISO15189醫學實驗室、或TFDA/LDTS實驗室。 2. 具次世代定序操作(Illumina、MGI、Ion Torrent)與應用經驗(WES、RNAseq等)。 3. 熟悉相關周邊儀器原理及使用(qPCR/BioAnalyzer/Fragment Analyzer/Qubit等。 4. 依據學歷及經歷調整薪資及助理研究員、副研究員或研究員職缺。

1.學名藥與新藥臨床一期試驗設計、計畫書撰寫、藥物動力學數據運算、試驗報告撰寫 2.臨床前藥物動力學數據計算與分析，試驗報告撰寫 3.藥物學術文獻彙整評估 4.法規單位函詢與意見回覆 5.台灣/歐美臨床試驗法規 6.一年以上相關工作經驗優先

工作地點：臺大醫院智慧醫療中心 職缺性質：兼職 1. 臺大醫院工作證申請: 於正式收案至少1.5個月前向台大臨床試驗中心申請臨床研究工作證（紅卡）暨研究案授權，確保取得工作證 2. 受試者招募: 試驗細節說明、協助受試者同意書簽署、依同意書資訊key-in受試者性別/年齡、給予受試者禮券(禮券保管) 3. NW500拍攝: 接受NW500拍攝訓練、拍攝眼底影像(一人2張)、每周整理NW500儲存的影像，提供給Sponsor 4. 配合Sponsor on-site monitoring活動 5. 醫院端庶務協助: 請PI/sub-I簽名相關文件、試驗文件管理與掃描歸檔、計畫經費核銷、協助儀器進出場相關事宜

- Responsible for all aspects of site management and monitoring of clinical trials - Manage interactions with all partners (investigators, site teams, internal company departments, external contractors, etc.) to facilitate successful conduct of clinical projects. - Support clinical research activities as assigned by the supervisor. - Build strong professional relationships with investigators, site staffs and internal/ external service providers. - Conduct initiation visits, monitoring visits and site closure visits in collaboration with the clinical project team. - Maintain the Trial Master File. - Prepare and negotiate site clinical trial agreements and manage clinical site budget and expenses. - Preparation of regulatory and ethics submission dossiers. - Ensure protocol-related safety reporting compliance and address and drive issue resolution. - Monitor site recruitment and establish/discuss action plans in close collaboration with the Clinical Project Manager. - Develop and conduct training for investigators and site staffs in the protocol, product and study-specific procedures. - Coordinate activities to ensure compliance with protocol, GCP, overall clinical objectives as well as company policies and SOP. - Manage trial product inventory, shipment and storage, and ensure accountability and traceability. - Ensure that imaging and/ or laboratory samples are collected, handled and shipped according to protocol requirements. - Ensure that safety reporting of adverse events is completed within required time periods. - Manage external vendor services for assigned clinical sites. - Identify issues which affect clinical trial progress and quality, and develop solutions and/ or take action to resolve/ prevent them. - Deliver projects according to expected targets, budgets and quality standards. - Monitor and report to clinical management teams on clinical trial progress, performance and plan, including subject recruitment and retention, monitoring activities, data completeness and quality, and site compliance. - Assist in the organization and conduct of internal and external stakeholder meetings, as required. - Set up, maintain and update clinical research activities and initiatives in the system.

工作內容： 1. 負責醫療設備與資訊系統（NIS、LIS）、醫院資訊系統（HIS）、自動化設備之整合與系統設定 2.執行設備通訊介接（如 ASTM、HL7、TCP/IP、RS-232 等），確保資料準確傳輸與自動上傳 3.安裝、設定並維護醫檢儀器相關的軟體與工作站系統 4.針對醫院端提供技術支援、故障排除與操作說明，提升設備資訊穩定性 5.協助完成新設備導入、測試、資料驗證（validation）與驗收作業 6.配合業務與應用團隊，參與客戶簡報、專案討論與客製化整合提案 職務需求： 1.資訊工程、生物醫學工程、醫學科技、自動控制或相關理工科系大學以上學歷 2.具基本網路架構與伺服器架設概念，能操作Windows Server、SQL、網路安全等基本設定 3.熟悉RS-232、HL7、LIS/HIS流程者佳 4.良好的溝通能力與問題分析能力，能配合現場作業與出差安裝需求 5.具備工作紀律，能獨立作業並處理多任務專案管理

• Proactively manage project level operational aspects including management of trial timeline, budget, resources, and vendors. • Provide efficient updates on trial progress to the Clinical Director and/or Senior management team, with respect to vendor selection, project plans, trial budget and timeline management, quality standards and risk mitigation. • Lead sponsor study startup process, including but not limited to conduct of the Trial Kick-off meeting, the set-up of trial master file (TMF), site selection and finalization of site and vendor Clinical Trial Agreements and budgets. • Ensure effective project plans are in place and operational for each trial and work proactively with the internal team/vendors to set priorities in accordance with applicable project plans, company standard operational procedures (SOPs), ICH/GCP guidelines and regulatory requirements. • Ensure potential study risks are escalated to the attention of the Clinical Director when appropriate. • Chair internal working group and vendor status update meetings and ensure meeting minutes are completed, distributed to team members and filed in the Trial Master File (TMF) in a timely manner. • Review and approve site visit reports; ensure tracking, follow up and resolution of site issues have been completed in a timely manner with internal team/CRO. • Monitor the quality of vendor deliverables, address quality issues with the appropriate team member and identify opportunities to improve training, execution and quality control across the clinical team. • Review and approve vendor invoices to ensure payments occur in a timely manner • Review and approve vendor responses to quality assurance audits for appropriateness, timeliness and accordance with company SOPs and regulatory requirements. • Ensure all project level study documentation is filed in the TMF in accordance with company SOPs/all regulatory requirements and provide oversight to the internal team/vendors regarding TMF filing, maintenance and archival procedure • Effectively provide support to CRO/internal team/vendors in the conduct of the trials • Support to development and review of SOPs and workflow

1.分子生物學實驗。 2.執行核酸純化方法設計、評估、驗證。 3.qPCR實驗設計、優化及執行，核酸檢驗試劑開發與驗證。 4.建立生產流程與品質檢測方法。 5.產品與技術相關 ISO 13485文件整理及撰寫。 6.主管交辦事項。

【關於我們】 陽光燦亮診所是一家前瞻醫美中心，同步投資自有生技實驗平台，專注於高分子與天然衍生新材料的開發與轉譯。我們相信，最尖端的醫美成果來自「專業醫學 × 研發實力」零距離的不斷迭代推陳出新。 【為什麼加入我們】 1. 直觀見證成果-新材料從概念到臨床應用的週期大幅縮短，研發成果能快速在醫美產業創造價值。 2. 跨域學習資源-與皮膚科、整形外科醫師及生醫材料、組織工程專家協作，掌握市場第一手趨勢。 3. 完整研發鏈-內建細胞／組織培養室、材料分析儀與 GLP 級測試流程（規劃中），並同步專利佈局、學術發表與臨床試驗。 想把前沿生技材料化為可實踐、具體的醫美價值？ 這裡就是能讓你看見影響力的舞台。 【職務內容】 1. 生物技術的評估、測試、分析與選擇 2. 醫療器材及其製造技術的評估、測試、分析與選擇 3. 既有產品或技術的優化與製程導入 4. 細胞與動物實驗驗證 5. 制訂產品檢驗標準 6. 其他主管交辦事項 一起開發下一代醫美材料，創造真正改變肌膚與自信的解決方案。 立即投遞履歷，和陽光燦亮診所共創未來！

細胞株開發是生物製藥產業的核心關鍵，直接影響後續藥物產量、品質與上市時程。本職務將加入我們的研發與開發團隊，負責哺乳動物細胞株（特別是 CHO 細胞）的建立、優化與工程設計，並參與從早期研究到 GMP 技術轉移的重要流程。這是一個能讓你結合專業技術與創新思維，推動新一代生物藥物平台發展的絕佳機會。 1) Cell Line Cultivation and Maintenance Perform hands-on cultivation, passaging, cryopreservation, and recovery of mammalian cell lines (CHO, HEK293, etc.). 2) Cell Line Screening and Workflow Optimization -Design and optimize cell line screening workflows to ensure timely and high-quality project delivery. -Experience with different types of CHO cell lines is welcome; not limited to any specific host type. 3) Cell Engineering and Genetic Modification (Preferred) Experience in CHO engineering is a strong plus, including practical application of CRISPR, transposon, or other genome editing tools for cell line development. 4) Cross-Functional Support and Laboratory Management 5) Assist in laboratory material and reagent management. Provide technical support across different functions and collaborate with R&D and process development teams. 6)Data Analysis and Presentation Effectively analyze experimental results and present findings through reports and presentations, with clear recommendations for improvements.

1. SAS programming for tables, figures and listing. 2. Protocol and synopsis design with statistical methodologies. 3. Project support / Statistical analysis. 4. Sample size estimation and power analysis. 5. Statistical analysis report/plan writing. 6. Communicate with client regarding to statistical issues.

主要職務: 1. New project evaluation, perform literature study 2. Pharmacology and PK/PD data interpretation 3. Assist nonclinical & clinical CRO management 4. Project management for new drug development 詳細職務內容: 1. In-depth study on marketed drugs and their target indications, consider MOA, PK/PD profile, formulation design, brainstorming for new project ideas. 2. Various literature search and information gathering per supervisor’s request 3. Assist in nonclinical study design. 4. Assist in CRO contracting and follow up study execution. 5. Data processing & provide scientific interpretation. 6. Serve as PM role in various projects, taking meeting minutes, tracking development progress

1) 分析方法開發與驗證(Analytical Method Development & Qualification) • 方法開發與應用： 針對核酸藥物, 基因治療和生物製劑產品，開發並應用多種細胞培養技術的分析方法，包括但不限於： • dPCR/qPCR： 用於檢測和定量特定核酸序列。 • ELISA： 用於檢測和定量蛋白質或抗體。 • 流式細胞術： 用於細胞表面標記物分析、細胞週期分析及細胞凋亡檢測。 • 功能性測試： 評估產品的生物活性或細胞反應。 • NGS (次世代定序)： 運用 NGS 技術進行更深入的基因體、轉錄體分析。 • 方法優化與驗證： 對開發的分析方法進行嚴謹的優化，以確保其準確性 (accuracy)、特異性 (specificity)、再現性 (reproducibility) 和穩定性 (stability)。 • 法規文件撰寫： 根據國際藥政法規（如 ICH、USP、FDA、EMA 等）的要求，撰寫詳細的方法開發報告 (Method Development Reports) 和方法驗證報告 (Method Qualification Reports)。 2) 細胞培養技術應用 (Cell Culture Techniques Application) • 培養並維持哺乳動物細胞，以進行細胞功能測試及藥效分析，包含操作P2等級病毒。 Maintain and monitor mammalian cell cultures, ensuring optimal growth conditions for functional assays, including handling P2 level viruses. • 監測細胞生長動態，調控培養條件，確保細胞健康度與試驗數據可靠性。Adjust culture conditions and monitor cell viability to ensure reliable test results. • 針對不同基因治療載體或 mRNA 藥物，建立適用的細胞模式，需具備P2實驗室操作經驗。 Establish cell-based assays to evaluate gene therapy vectors and mRNA drug candidates, requiring P2 laboratory operational experience. 3) 藥物開發支援 (Support for Drug Development) • 協助評估 基因治療與 mRNA 疫苗的效能、安全性與品質，提供開發與生產階段的分析數據。Assess the potency, safety, and quality of gene therapy and mRNA vaccine products. • 參與跨部門協作 (Cross-functional collaboration)，與 CMC、製程開發、生產 (Manufacturing) 等部門合作，提供分析方法技術支持。Collaborate with CMC, Process Development, and Manufacturing teams to provide analytical support. 進行技術轉移，將已開發的分析方法移轉至 QC (Quality Control) 或生產端。Facilitate technology transfer (Tech Transfer) of developed methods to QC and production departments.

The Researcher is responsible for the conduct of analysis related works according to GCP, GLP, CAP, Standard Operating Procedures (SOP), applicable Study Specific Procedures (SSP), and local regulatory requirements. Manage the operation of MT and aid physicians in the diagnosis, treatment, and prevention of diseases by testing patient specimens, correlating data, and reporting results in a timely manner to effect quality patient care. Responsibilities: Perform analysis work according to SOPs and guidance. Prepare, review, and approve various documents, including SOPs, protocols, reports, and analytical methods. Manage lab logistics, including purchasing, inventory control, and payment processing. Maintain instruments and ensure cleanliness and maintenance of the workspace. Take on the role of system owner for computerized systems, performing tasks such as validation tests, periodic reviews, and reporting. Attend training courses related to CAP/GCP/GLP/regulatory requirements. Study Based Responsibility (if needed) Analytical Study Director in Study Work as the Study Director, responsible for the overall conduct and final report of the study. Approve the study plan and any amendments by signature, and ensure Quality Assurance personnel receive timely copies. Make study plans, amendments, and SOPs available to study personnel. Ensure procedures in the study plan are followed and document deviations and take corrective action if necessary. Document and record all generated raw data. Validate computerized systems used in the study, sign and date the final report to indicate acceptance of responsibility for data validity, and ensure study materials are archived after completion. Study Personnel in Study Ensure personnel are knowledgeable in relevant Principles of Good Laboratory Practice. Provide study personnel with access to study plans and SOPs applicable to their involvement, with a responsibility to follow instructions and document any deviations. Emphasize the responsibility of all study personnel to promptly and accurately record raw data, comply with Good Laboratory Practice principles, and exercise health precautions to safeguard the integrity of the study.

1.本公司為專業營運規劃之顧問公司，專為企業提供創新產品與營運模式之整體營運規劃。 2.【研究員(生技領域)】職務內容主要配合資深顧問，參與企業診斷輔導，提供最適營運規劃，規劃內容包含: （1）負責生技新產品開發/新營運之整體規劃。 （2）進行生技產業競爭分析及策略規劃。 3.本公司具完善教育訓練與師徒制，在資深生技顧問與研究員帶領下，協助新進研究員內化專業技能。 4.研究員均擁有長期的培訓計畫，以培養專業顧問。 5.新進【研究員(生技領域)】提供完善培訓內容，進以培育優質未來的生技領域顧問專才。 6.新進【研究員(生技領域)】優質養成培訓內容 （1）企業創新營運架構分析。 （2）產業與競爭態勢分析。 （3）核心能耐與創新模式建構。 （4）營運風險與因應方案。 （5）智財權檢索與管理。 （6）行銷策略與競爭優勢規劃。 （7）企業與產業效益評估。 （8）創新營運模式可行性評估。 （9）投資與財務規劃。

此職務是連結研發與 GMP 生產的重要橋樑。您將不僅負責製程優化與放大，還需執行毒理批次 (Tox material) 生產，並承擔技術轉移 (Tech Transfer) 至 GMP 的任務。此角色同時涵蓋 MSAT (Manufacturing Science and Technology) 的核心功能，確保製程具備穩健性、可重現性與 GMP 導入準備。 1) Process Operations and Scale-Up - Manage and execute process operations ranging from 5 to 200 liters. - Ensure consistency, scalability, and reproducibility of upstream processes. 2) Tox Material Production - Lead the production of non-GMP toxicology batches to support preclinical studies. - Ensure materials meet quality standards and development timelines. 3) Process Optimization and DOE - Design and conduct experiments (DOE) to optimize upstream workflows. - Continuously improve existing processes for better yield, efficiency, and robustness. 4) Tech Transfer to CDMO - Prepare documentation and transfer processes to external CDMO partners. - Provide MSAT support to ensure smooth transition into GMP environments. 5) Cross-Functional Collaboration - Work closely with downstream, analytical, and quality teams to support integrated project needs. - Effectively communicate results and process improvements through reports and presentations. 6) Laboratory and Project Support - Assist in laboratory material management to ensure smooth operations. - Support other functional teams as needed to meet project goals.